![]() ![]() How the vessels in the brain become inflamed is not entirely clear. What causes central nervous system vasculitis? Nerve problems (including numbness, weakness and pain).Kidney problems (including dark or bloody urine).Sometimes certain medicines or illnesses can act as antigens and start this process. Substances that cause allergic reactions are called antigens. In most cases of vasculitis, something causes an immune or "allergic" reaction in the blood vessel walls. While the immune system usually works to protect the body, it can sometimes become "overactive" and attack the body. In most cases, the exact cause is unknown, but the immune system (which helps keep the body healthy) plays a role. It’s important to get treatment for this condition. In some cases, CNS vasculitis is life-threatening. The inflamed vessel wall can block the flow of oxygen to the brain, causing a loss of brain function and ultimately strokes. Is central nervous system vasculitis dangerous?ĬNS vasculitis is a serious condition. In this case, the vasculitis is only confined to the brain or the spinal cord and it’s referred to as primary angiitis of the CNS (PACNS). It can also occur without any associated systemic disorder. Systemic (affecting the whole body) vasculitic disorders, which include granulomatosis with polyangiitis GPA), eosinophilic granulomatosis with polyangiitis (EGPA), microscopic polyangiitis, cryoglobulinemic vasculitis and Behçet's syndrome).Accompanied by other autoimmune diseases such as systemic lupus erythematosus, dermatomyositis and rarely, sarcoidosis and rheumatoid arthritis.(The brain and the spine make up the central nervous system.) CNS vasculitis often occurs in the following situations: What is central nervous system vasculitis?Ĭentral nervous system (CNS) vasculitis is inflammation of blood vessel walls in the brain or spine. If blood flow in a vessel with vasculitis is reduced or stopped, the parts of the body that receive blood from that vessel begin to die. Vasculitis can affect very small blood vessels (capillaries), medium-size blood vessels (arterioles and venules) or large blood vessels (arteries and veins). Vasculitis is the inflammation (swelling) of the blood vessels, the network of hollow tubes that carry blood throughout the body.
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